Manish Srivastava Running the Gamut: From Nanotechnology to Macromolecules Nanobiotechnology: energy and synthesise a greater tonnage third section, comprising seven chapters, Concepts, Applications and of fine chemicals than the combined revolves around the use of DNA as a Perspectives global chemical industry. Mimicking the template for organising proteins and cre- Edited by C. Niemeyer and C. Wiley-VCH, Weinheim Conse- study, including atomic force micros- of the key incho- quently, there is a growing realisation copy and molecular pulling. This section- ate technologies that the new discipline of nanobiotech- al organisation seems somewhat illogical for the 21st cen- nology will provide the means to con- to the present reviewer, who would have tury.
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Manish Srivastava Running the Gamut: From Nanotechnology to Macromolecules Nanobiotechnology: energy and synthesise a greater tonnage third section, comprising seven chapters, Concepts, Applications and of fine chemicals than the combined revolves around the use of DNA as a Perspectives global chemical industry.
Mimicking the template for organising proteins and cre- Edited by C. Niemeyer and C. Wiley-VCH, Weinheim Conse- study, including atomic force micros- of the key incho- quently, there is a growing realisation copy and molecular pulling. This section- ate technologies that the new discipline of nanobiotech- al organisation seems somewhat illogical for the 21st cen- nology will provide the means to con- to the present reviewer, who would have tury. In reality, this struct, from the bottom-up, novel molec- preferred the work to commence with emerging field re- ular architectures with greater precision well chosen examples of the capabilities sides in the space and flexibility, and at lower cost, than of biology in data storage and handling, where the three traditional manufacturing processes.
In electron transfer, energy and signal major technologi- principle, entirely new classes of durable, transduction, motion and movement, cal domains of in- light and environmentally benign materi- liquid handling, catalysis and manufac- formation technology, materials science als, devices and systems could be creat- turing, decontamination and nanoparti- and biotechnology overlap, and there- ed to revolutionise the production of cle formation and self-assembly.
The second part would gins can be traced back tens if not hun- ment of entirely new approaches to the then describe the techniques currently dreds of years. However, the impact of construction of two- and three-dimen- being employed to promote the exem- modern biology has been profound; it sional nanoarchitectures formed on inor- plification of key biological functions can teach the physicochemical world of ganic, organic or biological templates.
The final part chemistry, materials science and manu- systematic and comprehensive frame- would concentrate on current thinking facturing a few lessons in how to assem- work of specific research topics in nano- on the applications of the biomimetic ble complex functional devices and sys- biotechnology and aims to provide in- systems in high-density data storage, tems that operate at the molecular level. The book is divided into four drug delivery and analytical science. The first, comprising Whilst it is recognised that the organisa- how to construct with conventional five individual chapters, covers what are tion of a multi-authored book covering a manufacturing technology by many referred to as interphase systems and in- multi-dimensional matrix of disciplines, orders of magnitude.
The tended application. ChemBioChem , 5, — www. KGaA, Weinheim Organisation apart, the book covers a Biophysical Chemistry remaining 5 pages gives brief accounts wide range of techniques, capabilities By A. These include determina- and applications. Each individual chapter tion of the relative mass of proteins, se- is formatted to include a brief overview, Royal Society of Chemistry, Cambridge A student will reader with the most relevant tech- not become an expert on any of these niques, an outlook to provide the appli- through reading this chapter but they cations and experimental challenges to For some years I have contributed to a will be alerted to what is possible and be addressed and an up-to-date to 2nd-year biochemistry lecture unit on obtain some understanding of how par- list of key references.
Needless to biophysical chemistry: a series of lec- ticular methods work. The same ap- say, individual chapters vary in length tures, workshops and laboratory practi- proach is used in other chapters.
Thus, 6—21 pages , style prosaic to thought cals on the size, shape and stability of for example, the 23 page chapter on provoking and impact limited applica- proteins, and methods for their investi- thermodynamics and interactions consid- bility to substantial markets , but are gation.
These methods include electro- ers methods such as differential scan- generally well laid out and complement- phoresis, analytical ultracentrifugation, ning calorimetry, isothermal titration cal- ed with adequate figures, tables and ref- and fluorescence and CD spectroscopies. All mineralisation, epitaxial stratification of ence, including intermolecular interac- this after discussing the basics of molec- inorganic materials by using biolinkers, tions, and protein structure and its de- ular thermodynamics in just 4 pages!
Though I like the way that Cooper has bioanalytical sensors would have been One thing that has handicapped me treated biophysical chemistry and think useful. However, the reader should not with this unit has been the lack of a suit- that this is a good book for students, it be fooled into thinking that everything able textbook covering all the material I cannot be the only book they use.
The contained within this book is conceptu- teach on it in the way I want it taught. Many of the ideas have been As a consequence I provide detailed referred to above illustrates why. Just 4 around for some time, nanoparticles notes, though each year students lament pages for the basics means that entropy, since the midth century, particle the lack of a textbook. But no more lam- enthalpy, Gibbs free energy and chemi- assays since the early 20th century and entations I hope.
Biophysical Chemistry cal equilibrium are introduced in a con- most of the rest have been articulated by Alan Cooper is just the book I and cise way that should lead enterprising over the last few decades. However, it is my students need. In a slim and there- students to want to know more, and important to realise that it is the tech- fore inexpensive volume Cooper covers among the topics not mentioned that I niques and putative applications that a wide variety of biophysical subjects in- would have expected in a course on bio- have moved ahead at breathtaking cluding: spectroscopy, mass spectrom- physical chemistry are ionic strength and speed rather than the ideas per se.
But then a book cover- This book really does represent a fine and intermolecular interactions, kinetics, ing the techniques this one does togeth- collection of chapters by respected au- chromatography and electrophoresis, er with a detailed treatment of the un- thors describing current thinking on this and methods for studying single mole- subject.
The book represents a substan- cules. Though there is an introductory tial and realistic compendium of the key chapter on biological molecules 17 concepts and realities of modern nano- pages most readers of this book will biotechnology and should be on the have access to more extensive treat- purchase list of all biologists, chemists, ments of these in one of the many core physicists and engineers wishing to ac- general biochemistry textbooks.
The real quaint or immerse themselves in this strength of the book is the breadth of newly emerging technology. There are physical topics covered and the way in few other sources of such a comprehen- which they are described.
To illustrate what is good about the Christopher R. Lowe book, consider the 12 page chapter on University of Cambridge UK mass spectrometry. This explains the DOI: KGaA, Weinheim www.
Nanobiotechnology. , Concepts, applications and perspectives
This article has been retracted. The retraction notice can be found here. The Retraction Note to this article has been published in Journal of Nanobiotechnology Abstract Background Nanobiotechnology is the application of nanotechnology in biological fields. Nanotechnology is a multidisciplinary field that currently recruits approach, technology and facility available in conventional as well as advanced avenues of engineering, physics, chemistry and biology. Method A comprehensive review of the literature on the principles, limitations, challenges, improvements and applications of nanotechnology in medical science was performed.
Nanobiotechnology Concepts Applications And Perspectives