LYOPHILIZER PRINCIPLE PDF

Lyophilizer vs. Freeze Dryer What is a lyophilizer? How does it work? A lyophilizer executes a water removal process typically used to preserve perishable materials, to extend shelf life or make the material more convenient for transport.

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What is a Lyophilizer? How does it work? View Larger Image Lyophilizer , also known as freeze dryer or liofilizador, they are synonymous. Lyophilizer works by freezing the material, then reducing the surround to allow the frozen water ice to sublimate. That means, a lyophilizer will have systems of: refrigeration, vacuum, heating, drying chamber, vapor collect condenser and controller, as well as the auxiliary components like temperature probes, vacuum sensors, software and so on.

Sublimation is the process of transition of a substance from solid to the vapor state without passing through an intermediate liquid phase. The process of lyophilization consists of: Freezing of the product to convert the water in the product to ice form, Sublimation of ice directly into water vapor under vacuum. Drawing off the water vapor Once the ice has been sublimated, the products are freeze-dried and can be removed from machine.

Freezing Phase A lyophilizer uses various methods to freeze the product. Freezing can be done in a freezer, a chilled bath shell freezer , or on a shelf in the lyophilizer. The lyophilizer cools the material below its triple point to ensure that sublimation, rather than melting, will occur.

A lyophilizer most easily freeze dries large ice crystals, which can be produced by slow freezing or annealing. However, with biological materials, when crystals are too large they may break the cell walls, and that leads to less-than-ideal freeze drying results. To prevent this, the freezing is done rapidly. For materials that tend to precipitate, annealing can be used. This process involves fast freezing, then raising the product temperature to allow the crystals to grow. The condenser also protects the vacuum pump from the water vapor.

Primary drying can be a slow process. Too much heat can alter the structure of the material. By raising the temperature higher than in the primary drying phase, the bonds are broken between the material and the water molecules.

Freeze dried materials retain a porous structure. After the lyophilizer completes its process, the vacuum can be broken with an inert gas before the material is sealed.

Eutectic point freezing point , which mentioned above, is the lowest temperature that could completely freezing material to solid. Proper give energy in sublimation step Heating the product too high in temperature can cause many troubles: Product melt. For example, carbohydrate will block the vapor channel, cause drying fail. Too much vapor creation. Condenser cannot collect in time, and the temperature will have a drastic raise.

Vacuum pump broken. Vapors that cannot collect by condenser in time may go to vacuum pump, oil pump will broken. Related Products.

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Freeze-drying

What is a Lyophilizer? How does it work? View Larger Image Lyophilizer , also known as freeze dryer or liofilizador, they are synonymous. Lyophilizer works by freezing the material, then reducing the surround to allow the frozen water ice to sublimate. That means, a lyophilizer will have systems of: refrigeration, vacuum, heating, drying chamber, vapor collect condenser and controller, as well as the auxiliary components like temperature probes, vacuum sensors, software and so on.

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Basic Principles of Freeze Drying

Product Chamber or Manifold Condenser The refrigeration system cools the ice condenser located inside the freeze dryer. The refrigeration system can also be employed to cool shelves in the product chamber for the freezing of the product. The vacuum system consists of a separate vacuum pump connected to an airtight condenser and attached product chamber. Control systems vary in complexity and usually include temperature and pressure sensing ability. Choosing a control system for the freeze dryer depends on the application and use i. Product chambers are typically either a manifold with attached flasks, or, a larger chamber with a system of shelves on which to place the product.

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